Abstract:
Objective To explore the efficacy of interferon combined with xiyanping injection in the treatment of pediatric mumps.
Methods 69 cases of children with mumps admitted to our hospital from May 2021 to August 2023 were screened as research subjects and divided into control group (n=35) and observation group (n=34) according to randomized numerical table method. The control group received interferon intramuscular injection, and the observation group added Xiyanping injection for intravenous drip on the basis of the treatment in the control group, and both groups were treated for 3~5 d, and were observed until they were discharged from the hospital. The clinical efficacy, temperature recovery time, parotid swelling time, neck resistance disappearance time, serum interleukin-4 (IL-4), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) levels before and after treatment, and the occurrence of adverse reactions during hospitalization were compared between the two groups.
Results The total clinical effective rate after treatment of the observation group was higher than that of the control group (P<0.05); the recovery time of body temperature, the time of parotid gland swelling, and the disappearance of neck resistance of the observation group were shorter than that of the control group (P<0.05). Serum IL-4, IL-8 and TNF-α levels after treatment were lower in the observation group than in the control group (P<0.05).
Conclusion Interferon combined with Xiyanping injection can promote the recovery of symptoms and reduce the inflammatory reaction in children with mumps, and the therapeutic effect is accurate.
