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Biljana Vuletic, Speaker at Neonatology Conferences
University of Kragujevac,Serbia, Romania


The first consensus on definitions in the field of probiotics between the FAO (Food and Agriculture Organization of the United Nations) and the World Health Organization (WHO) was adopted in 2001. Then, probiotics were defined as “live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host” but already in the following year, in 2002, the FAO/WHO working group issued more detailed instructions on the interpretation of the document produced. Several professional associations reached the agreement on the assessment of probiotics based on the results from available clinical studies according to “evidence-based medicine” which lead to the clinical recommendation. They refer to specific clinical indications such as the treatment and prevention of acute gastroenteritis (AG) in children and adults (Lactobacillus rhamnosus LGG, Lactobacillus casei, Lactobacillus reuteri, Saccharomyces boulardi), necrotizing enterocolitis (NEC), antibiotic-associated diarrhoea (LGG, L. casei, Saccharomyces boulardi), irritable colon, infant colic (Bacillus infantis and L. reuteri), in the case of H. pylori eradication, mild ulcerative colitis (UC) with the probiotic VSL#3, but with disappointing results in the remission of Crohn’s disease and prevention of food allergy. Conclusion: The capacity of probiotics to cure illnesses and relieve symptoms varies between different strains, drawing the conclusion of their uneven efficacy and appropriateness in the treatment of every illness conditions. Special caution is advised in immunocompromised and severely ill patients in the Intensive Care Unit (ICU). Keywords: probiotics, children, gut health


Biljana Vuletic, MD, PhD is Associate Professor of Pediatrics at the Faculty of Medical Scineces University of Kragujevac and Chief of the Department of Gastroenterology of Pediatric clinic and a full ESPGHAN member. Dr Vuletic recived her medical degree from the Medical faculty University of Belgrade. She started her residency in Pediatrics at the University Children s Hospital University of Belgrade. Her mainly cliical interests include chronic intestinal failure, Coeliac disease and others autoimunnity disorders and a clinical nutrition. Prof. Vuletić has summary 168 publications including authored or co-authored papers in peer-reviewed journals and also chapters in the national Monographs and Textbooks published in Serbia.