EPN 2019

Wendy N Phoswa

Wendy N Phoswa, Speaker at Wendy N Phoswa: Speaker for Pediatrics Conference
University of KwaZulu-Natal, South Africa
Title : The role of highly active antiretroviral therapy (HAART) on interleukin 17A (IL17A) in normotensive and pre-eclamptic black south african women

Abstract:

Introduction: Interleukin 17-A (IL-17A) has been implicated in the pathophysiology of both human immune deficiency virus (HIV) and preeclampsia (PE). This study evaluated serum levels of IL-17A in HIV-negative and HIV-positive normotensive and preeclamptic women receiving highly active anti -retroviral therapy (HAART). Material and Methods: A sample size of 250 was analysed. Normotensives (n=150; N), pre-eclamptics (n=100; PE). Normotensives were further stratified into HIV negative (n=90), HIV positive (HAART: acute) (n=30) and HIV positive (HAART: chronic) (n=30). The PE group was divided into early onset (n=50; EOPE) and late-onset (n=50; LOPE). The EOPE and LOPE groups were subdivided into HIV negative (n=30), HIV positive (HAART: acute) (n=10), and HIV positive (HAART: chronic) (n=10). Analysis of IL-17A was performed using multiple Bio-Plex immunoassay method. Results: With regards:- Pregnancy type; The levels of IL-17A were significantly increased in N compared to PE (P= 0.0012). Gestational age; The levels of IL-17A were significantly different between (N vs EOPE vs LOPE) (P=0.0044). The levels of IL-17A were significantly increased in N compared to the EOPE (P=0.0113) and between N compared to the LOPE (P= 0.0063). HIV status; The levels of IL-17A were significantly increased in HIV negative N compared to LOPE (P= 0.0429). HAART duration; HAART-chronic: The levels of IL-17A were significantly increased in (N vs PE) (P=0.0086), (N vs EOPE vs LOPE) (P= 0.0179) and N vs EOPE (P=0.0042). Conclusion: The study demonstrates that IL-17A is involved in maintaining normal pregnancy and that reduction in IL-17A is involved in the pathophysiology of PE.

Biography:

Ms. Wendy N Phoswa enrolled for BSc Medical Science at the University of KwaZulu Natal, South Africa in 2011 and graduated in 2015. She then did her BSc honours In Medical Science (Physiology) and graduated in 2016. She enrolled for a Master’s degree in Medical Science in Physiology and graduated (Summa cum Laude) in 2017. She is currently enrolled for PhD in Medicine at the University of KwaZulu Natal (Nelson R Mandela School of Medicine) looking at immune markers and gene polymorphisms in HIV associated pre-eclamptic pregnancies. Miss Phoswa is also working as a Physiology Lecturer at the University of South African. She has published 3 research articles.

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