Abstract:
Background: We aim to investigate the incidence and perinatal risk factors of cranial ultrasound(CUS) abnormalities in hospitalized neonates,build new reference values of cerebral parameters in newborns.
Methods:All CUS data of newborns hospitalized in the First Affiliated Hospital of Xi'an Jiaotong University from January 2019 to June 2022 were collected. Univariate analysis and multinomial logistic regression were used to evaluate the influence of different variables on cranial performance.
Results:Abnormal CUS images were found in 728/1728 hospitalized infants(42%),which mainly included intraventricular hemorrhage(25%),periventricular white matter echogenicity(11.4%) and choroid plexus cyst(4.2%).Small gestational age, in vitro fertilization and embryo transfer, Apgar?7, congenital heart disease , neonatal respiratory distress syndrome and hypothyroidism of mother were related to abnormal cranial performance. 1000 normal cranial data were used to plot the reference range curves of frontal lobe thickness,transverse cerebral diameter and hemodynamics parameters of 24-42 weeks’ gestation.With the increase of gestational age, frontal lobe thickness, transverse cerebral diameter increased significantly and hemodynamics parameters tended to level off.
Conclusion:We recommend the new reference criteria for brain volume parameters and hemodynamics for hospitalized newborns.CUS monitor in early stage is critical for infants with high-risk factors,which promotes the timely detection of abnormalities and the reduction of neonatal mortality.
Audience Takeway
- This large sample study firstly investigated the occurrence characteristics of cranial ultrasound screening abnormalities in hospitalized newborns in Northwest China.
- We established new reference ranges for early postnatal cerebral measurements and hemodynamics in neonates of different gestational ages?which can be applied and improved in other areas.
