Abstract:
The study group included 106 patients with acute lymphoblastic leukaemia from B-cell progenitor cells aged 1 to 17 years receiving specific therapy. We have studied the prevalence of polymorphisms in cytochrome P450 genes (CYP1A1, CYP2E1, CYP2D6) and to analyze their association with the likelihood of complications during polychemotherapy of acute lymphoblastic leukemia in children. We established associations of the A2455G polymorphism (rs1048943) in the CYP1A1 gene with a high frequency of grade 3-4 toxic peripheral polyneuropathy; the heterozygous CT allele in the CYP1A1 gene (T3801C, rs4646903) with grade 3-4 toxic complications of the central nervous system; the mutant TT allele when determining the C-1053T polymorphism (rs2031920) in the CYP2E1 gene with a high risk of allergic reactions in the form of bronchospasm and anaphylaxis; the heterozygous A/del allele of the A2549del polymorphic variant (rs35742686) in the CYP2D6 gene with acute pancreatitis; polymorphism A2549del (rs35742686) in the CYP2CD6 gene with the probability of developing hyperglycemia over 13.9 mmol/l.
