Neonatal extubation, a critical component of Paediatric intensive care, is a delicate and multifaceted procedure that marks the transition from artificial ventilation to spontaneous breathing in newborns. This intricate process requires the expertise of a skilled neonatal care team, encompassing neonatologists, respiratory therapists, and nurses, who collaborate seamlessly to ensure the successful removal of an endotracheal tube from the fragile airways of infants who have been mechanically ventilated. As neonatal patients are particularly vulnerable, the extubation process demands meticulous attention to detail and thorough assessment of the newborn's respiratory status, cardiovascular stability, and overall health. Factors such as gestational age, birth weight, underlying medical conditions, and the primary reason for intubation play pivotal roles in determining the optimal timing and approach for extubation. The gradual weaning of respiratory support and the implementation of non-invasive ventilation strategies, such as continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP), often precede extubation attempts. Continuous monitoring of vital signs, blood gases, and respiratory parameters is paramount during this transitional phase to promptly identify and address any signs of respiratory distress or instability. Communication and collaboration among healthcare professionals are essential to navigate the intricate decision-making process, considering the delicate balance between providing adequate respiratory support and minimizing the potential risks associated with prolonged intubation. Successful neonatal extubation signifies a crucial milestone in the neonate's journey towards independent breathing and marks a significant step in their overall recovery. This intricate procedure exemplifies the intersection of medical expertise, technological advancements, and compassionate care in the delicate realm of neonatal medicine, where each decision profoundly influences the short- and long-term outcomes of these vulnerable patients.