Paediatric Rhinovirus Infection, a prevalent respiratory ailment primarily affecting children, emerges as a significant clinical concern due to its widespread prevalence and consequential impact on Paediatric health. This infection is predominantly caused by the rhinovirus, a member of the Picornaviridae family, and manifests as a spectrum of upper respiratory tract illnesses ranging from the common cold to more severe conditions such as bronchiolitis and pneumonia in infants and young children. The virus gains entry through the nasal mucosa, exploiting its affinity for the respiratory epithelium, where it proliferates rapidly, triggering a cascade of immune responses. Clinical manifestations include nasal congestion, rhinorrhea, sneezing, coughing, and fever, presenting diagnostic challenges as symptoms often overlap with other respiratory infections. In Paediatric populations, the consequences of rhinovirus infection extend beyond the immediate illness, contributing to increased healthcare utilization, missed school days, and parental absenteeism from work. Furthermore, the virus exhibits a remarkable capacity for mutation, presenting challenges for vaccine development. The epidemiology of Paediatric rhinovirus infection underscores its seasonality, with peaks occurring in the fall and spring, coinciding with the start of the school year and increased community interactions. Although generally self-limiting, severe cases may necessitate hospitalization, particularly in children with underlying respiratory conditions. Diagnosis relies on clinical evaluation, but advances in molecular diagnostics, such as polymerase chain reaction (PCR), have enhanced the accuracy of detection. Management primarily involves supportive care, with antiviral medications showing limited efficacy. Prevention strategies encompass hand hygiene, environmental measures, and, potentially, the development of vaccines targeting specific rhinovirus serotypes. The intricate interplay between host factors, viral characteristics, and environmental influences complicates the understanding of Paediatric rhinovirus infection, urging continued research efforts to refine preventive measures and therapeutic interventions, ultimately mitigating the burden on Paediatric healthcare systems and improving the overall well-being of affected children.